Most patients report noticing subtle benefits like improved sleep, increased energy and some fat loss within the first month or two of beginning HGH therapy. As treatment continues and hormonal balance is restored over 3-6 months, the benefits intensify – body composition improves, muscle tone increases, fine lines and wrinkles show signs of smoothing, immunity strengthens and cognitive function gets a boost. Patients in their late 30s to 60s see the most dramatic changes, including body fat reduction up to 14% and muscle gain exceeding 8 pounds. With continued therapy, most are able to sustain a vibrant, youthful appearance and wellbeing for the long term.